发明名称 |
Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects |
摘要 |
This invention relates to a method for selectively enhancing the analgesic potency of a bimodally-acting opioid agonist such as tramadol and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of the bimodally-acting opioid agonist. The method of the present invention comprises administering to a subject an analgesic or sub-analgesic amount of a bimodally-acting opioid agonist such as tramadol and an amount of an excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of the bimodally-acting opioid agonist and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of the bimodally-acting opioid agonist. |
申请公布号 |
AU4992800(A) |
申请公布日期 |
2000.11.21 |
申请号 |
AU20000049928 |
申请日期 |
2000.05.05 |
申请人 |
PAIN THERAPEUTICS, INC.;ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
STANLEY M CRAIN;KE-FEI SHEN;BARRY SHERMAN;MARY REMIEN;REMI BARBIER;NADAV FRIEDMANN |
分类号 |
A61K45/00;A61K31/00;A61K31/137;A61K31/485;A61K38/33;A61P25/04;A61P43/00;G01N33/94 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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