AN ATTENUATED BORDETELLA BRONCHISEPTICA (BBS) STRAIN AND METHOD FOR PRODUCING THEREOF, AN IMMUNOGENIC COMPOSITION COMPRISING THE STRAIN AND A METHOD OF TREATING OR PREVENTING BBS INFECTION FROM MAMMALS USING THE SAME
摘要
An attenuated Bordetella bronchiseptica(BBS) strain is provided to exhibit immunogenicity and show attenuated toxicity, thereby being be used as a live vaccine. An immunogenic composition comprising the same is provided to induce production of an antibody against BBS toxin in case of being administered into mammal. An attenuated BBS strain is characterized in that an aroA gene is deleted therefrom through homologous recombination and is deposited as a deposition no. KCCM-10840P. An immunogenic composition for treating or preventing BBS infection of mammal comprises the attenuated BBS strain and a pharmaceutically acceptable carrier or an adjuvant. Further, the aroA gene has SEQ ID : NO. 1.
申请公布号
KR20080082883(A)
申请公布日期
2008.09.12
申请号
KR20070047287
申请日期
2007.05.15
申请人
INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
发明人
KIM, TAE JUNG;LEE, BONG JOO;LEE, JAE IL;KO, HYUK JU;SEO, JA YOUNG;PYO, HYO JU;LEE, SE MI;JUNG, BOCK GIE