发明名称 |
NANOEMULSION THERAPEUTIC COMPOSITIONS AND METHODS OF USING THE SAME |
摘要 |
The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications. |
申请公布号 |
US2016158179(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
US201615041173 |
申请日期 |
2016.02.11 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
Baker, Jr. James R.;Hemmila Mark R.;Wang Stewart C.;Hamouda Tarek;LiPuma John J.;Knowlton Jessica Ann;Makidon Paul E.;Blanco Luz;Groom, II Jeffery V.;Bielinska Anna U. |
分类号 |
A61K31/198;A61K31/4425;A61K45/06;A61K31/047;A61K31/14;A61K9/107;A61K31/341;A61K31/045 |
主分类号 |
A61K31/198 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a wound infection comprising administering a composition comprising a therapeutically effective amount of a nanoemulsion to the wound infection, wherein the nanoemulsion comprises:
1. 30-90%, 60-80%, or 60-70% by volume oil; 2. 3-15% by volume solvent; wherein said solvent is selected from the group consisting of ethanol and glycerol; 3. 0.05-10.0% by volume non-ionic surfactant and 0.001-5.0% by volume cationic surfactant; 4. ethylenediaminetetraacetic acid (EDTA); and 5. water. |
地址 |
Ann Arbor MI US |