Histone demethylase inhibitors

摘要

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

主权项

1. A compound of Formula (I), or pharmaceutically acceptable salt thereof, wherein, R is hydrogen or alkyl; G is —X—Y; X is unsubstituted —C1-C5 alkylene, unsubstituted —(C1-C5 alkylene)—Z—(C1-C5 alkylene)—, or unsubstituted —(C1-C5 alkylene)—Z—; Y is unsubstituted carbocyclyl, unsubstituted heterocyclyl, unsubstituted aryl, or unsubstituted heteroaryl; and  and n is 0, 1, 2, or 3; Z is unsubstituted with the provision: G is not