发明名称 |
<i>H. pylori </i>lipopolysaccharide outer core epitope |
摘要 |
Helicobacter pylori, one of the most common human pathogens, is associated with the development of human chronic gastritis, peptic ulcers and gastric cancer. The invention relates to a α1,6-glucan-containing Helicobacter pylori compound comprising the structure of Formula I:;
wherein R is a α-DDHep-3-α-L-Fuc-3-β-GlcNAc trisaccharide substituted with an α1,6-glucan linked to an α1,3-DD-heptan, and wherein the last DD-Hep residue of α1,3-DD-heptan is capped with β-GlcNAc residue. Compositions comprising the compound, uses of the compound, and antibodies raised against the compound are also described. |
申请公布号 |
US9475863(B2) |
申请公布日期 |
2016.10.25 |
申请号 |
US201514739013 |
申请日期 |
2015.06.15 |
申请人 |
National Research Council of Canada |
发明人 |
Altman Eleonora;Harrison Blair A.;Chandan Vandana |
分类号 |
A61K39/395;A61K39/40;C07K16/12;C08L5/02;A61K39/02;A61K47/48;C08B37/00;C08L5/00;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
Ade & Company Inc. |
代理人 |
Williams Michael R.;Ade & Company Inc. |
主权项 |
1. A monoclonal antibody that specifically binds to an α1,6-glucan-containing Helicobacter pylori compound comprising the structure of Formula I: wherein the R is a α-DDHep-3-α-L-Fuc-3-β-GlcNAc trisaccharide substituted with an α1,6-glucan comprising from 4 to 12 α1,6-linked glucose residues linked to an α1,3-DD-heptan, wherein the last DD-Hep residue of the α1,3-DD-heptan is capped with β-GlcNAc residue. |
地址 |
Ottawa Ontario CA |