发明名称 Substituted oxopyridine derivatives and use thereof as factor xia/plasma
摘要 The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
申请公布号 US9475809(B2) 申请公布日期 2016.10.25
申请号 US201414906771 申请日期 2014.07.21
申请人 Bayer Pharma Aktiengesellschaft 发明人 Röhrig Susanne;Hillisch Alexander;Straβburger Julia;Heitmeier Stefan;Schmidt Martina Victoria;Schlemmer Karl-Heinz;Buchmüller Anja;Gerdes Christoph;Teller Henrik;Schäfer Martina;Tersteegen Adrian
分类号 C07D471/04;C07D401/12;C07D221/04;C07D413/12;C07D215/227 主分类号 C07D471/04
代理机构 代理人 Mehta Aseem
主权项 1. A compound of the formula in which n represents the number 1 or 2, A represents —N(R2)—or —CH2—, whereinR2 represents hydrogen or C1-C4-alkyl, R1 represents a group of the formula where * is the point of attachment to the oxopyridine ring,R6 represents bromine, chlorine, fluorine, methyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy,R7 represents hydrogen, bromine, chlorine, fluorine, cyano, nitro, hydroxy, methyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy, trifluoromethoxy, ethynyl, 3,3,3-trifluoroprop-1-yn-1-yl or cyclopropyl,R8 represents hydrogen, chlorine or fluorine, R3 represents hydrogen, R4 represents hydrogen, R5 represents a group of the formula where # is the attachment site to the nitrogen atom,R9 represents hydroxycarbonyl or 5-membered heterocyclyl, where heterocyclyl may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of oxo, hydroxy, thioxo, sulphanyl, methyl, difluoromethyl, trifluoromethyl, 2-hydroxycarbonyl-1,1,2,2-tetrafluoroethyl and 2-methoxycarbonyl-1,1,2,2-tetrafluoroethyl, where methyl may be substituted by a methoxy substituent,R10 represents hydrogen, chlorine, fluorine or methyl,R11 and R12 together with the carbon atoms to which they are bonded form a 5-membered heterocycle, where the heterocycle may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of oxo, chlorine, hydroxy, hydroxycarbonyl, methyl, difluoromethyl, trifluoromethyl, 1,1,2,2,2-pentafluoroethyl, 2-hydroxycarbonyl-1,1,2,2-tetrafluoroethyl and 2-methoxycarbonyl-1,1,2,2-tetrafluoroethyl,R13 represents hydrogen, chlorine, fluorine, methyl or methoxy, or one of the salts thereof.
地址 Berlin DE
您可能感兴趣的专利