Compounds as tyrosine kinase modulators

摘要

The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors.;

主权项

1. A compound represented by Formula I: or a pharmaceutically acceptable salt thereof, wherein:
X is NH;RI is selected from the group consisting of a is 0 or 1;RII is independently selected from the group consisting of hydrogen and NH2;b is 0 or an integer of from 1 to 2;Y is selected from the group consisting of  and a single bond;Ring A in the structure is phenyl;RIII represents optionally halogen;Z is selected from the group consisting of Ring B in the structure is selected from the group consisting of:
(i′) phenyl;(ii′) thienyl; and(iii′) furoyl; andRIV represents optionally 1-3 substituents, independently selected from the group consisting of methyl and halogen.