发明名称 |
ANTISENSE GENE THERAPY FOR RNA VIRUSES |
摘要 |
A vector and methods of inhibiting replication of an RNA virus which replicates in the cytoplasm of a cell in a subject, comprising administering to the cell of the subject a composition comprising a vector comprising a promoter functionally linked to a nucleic acid comprising a viral gene, wherein the nucleic acid is in antisense orientation relative to the promoter and wherein the cell is capable of promoting expression from the promoter, thereby transcribing the nucleic acid and inhibiting replication of the RNA virus in the subject. In particular, provided are vectors and methods for treating a respiratory syncytial virus infection.
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申请公布号 |
WO9812312(A1) |
申请公布日期 |
1998.03.26 |
申请号 |
WO1997US16628 |
申请日期 |
1997.09.18 |
申请人 |
VANDERBILT UNIVERSITY;WRIGHT STATE UNIVERSITY;STECENKO, ARLENE;BERNSTEIN, JACK, M. |
发明人 |
STECENKO, ARLENE;BERNSTEIN, JACK, M. |
分类号 |
A61K38/00;C12N15/113;(IPC1-7):C12N15/00;C12N5/10;A61K31/395 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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