| 发明名称 |
ENDOTHELIN N-[[2-[[(4,5-DIMETHYL-3-ISOXAZOLYL)AMINO]SULFONYL]-4-(2- OXAZOLYL)]-1,1-BIPHENYL]-2-YL]METHYL]-N,3-3-TRIMETHYLBUTANAMIDE AND N-(4,5-DIMETHYL-3-ISOXAZOLYL)-2 -[(3,3-DIMETYL-2-OXO-1-PYRROLIDINYL)METHYL]- 4-(2-OXAZOLYL)-[1,1 -BIPHENYL]-2-SULFONAMIDE ANTAGONISTS AND SALTS THEREOF |
| 摘要 |
<p>The compounds N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide, and salts thereof, useful as endothelin antagonists.</p> |
| 申请公布号 |
CZ9902362(A3) |
申请公布日期 |
1999.11.17 |
| 申请号 |
CZ19990002362 |
申请日期 |
1998.01.26 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
MURUGESAN NATESAN;BARRISH JOEL C.;GU ZHENGXIANG;MORRISON RICHARD A. |
| 分类号 |
A61K31/422;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P11/00;A61P11/06;A61P13/08;A61P13/12;A61P25/06;A61P43/00;C07D261/00;C07D263/00;C07D413/12;C07D413/14;(IPC1-7):C07D413/12;A61K31/42 |
主分类号 |
A61K31/422 |
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