摘要 |
A compound of formula (I) and its pharmaceutically acceptable salt, wherein A is hydrogen, hydroxy or OY, wherein Y is a hydroxy protecting group; Ar is phenyl optionally substituted with one or more substituents selected from halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, CF3, C1-C4 alkoxy-C1-C4 alkyloxy, and carboxy-C1-C4 alkyloxy; X is phenyl, naphthyl, biphenyl, indanyl, benzofuranyl, benzothiophenyl, 1-tetralone-6-yl, C1-C4 alkylenedioxy, pyridy l, furyl and thienyl, these groups optionally being substituted with up to thre e substituents selected from halo, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, NO2, CF 3 and SO2CH3; and R is hydrogen, C1-C4 alkyl or a hydroxy protecting group. These compounds and pharmaceutical compositions containing them are useful a s analgesic, anti-inflammatory, diuretic, anesthetic or neuroprotective agents , or an agent for stroke or treatment of functional bowel diseases such as abdominal pain, for the treatment of a mammalian subject, especially a human subject. Further, the present invention provides processes for producing the hydroxamic compounds of formula (I) and their intermediate compounds of formula (II). |