发明名称 |
Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase |
摘要 |
Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
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申请公布号 |
US2008070895(A1) |
申请公布日期 |
2008.03.20 |
申请号 |
US20070899844 |
申请日期 |
2007.09.07 |
申请人 |
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发明人 |
COLLINS IAN J.;COOPER LAURA C.;HARRISON TIMOTHY;KEOWN LINDA E.;MADIN ANDREW;RIDGILL MARK P. |
分类号 |
C07D285/14;A61K31/397;A61K31/433;A61K31/4439;A61K31/5377;A61P25/28;C07D401/00;C07D417/00 |
主分类号 |
C07D285/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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