发明名称 |
CLOSTRIDIAL NEUROTOXIN FUSION PROTEINS, PROPEPTIDE FUSIONS, THEIR EXPRESSION, AND USE |
摘要 |
The present invention is directed to a fusion protein comprising a light chain region of a Clostridial neurotoxin and a heavy chain region of a Clostridial neurotoxin, where the light and heavy chain regions are linked by a disulfide bond. The fusion protein also has a single chain antibody positioned upstream of the light chain region, where the single chain antibody possesses antigen-binding activity. Also disclosed are therapeutic agents, treatment methods, propeptide fusions, isolated nucleic acid molecules, expression systems, host cells, and methods of expressing fusion proteins. |
申请公布号 |
WO2016094555(A1) |
申请公布日期 |
2016.06.16 |
申请号 |
WO2015US64787 |
申请日期 |
2015.12.09 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
ICHTCHENKO, KONSTANTIN;VAZQUEZ-CINTRON, EDWIN;BANK, PHILIP, A.;CARDOZO, TIMOTHY |
分类号 |
C12N15/63;C12N15/70 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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