Aptamer-modified polymeric materials for the binding of factors in a wound environment

摘要

The present invention provides aptamer-modified polymers and materials thereof, which may be used for the binding of factors in a wound bed. For example, the aptamer-modified materials can be polypeptides conjugated to polymer foam materials. Such materials may be used, for example, for dressings, wound inserts, or pads.

主权项

1. A wound dressing comprising a polyurethane foam substrate, wherein the polyurethane foam substrate comprises a co-polymer, and wherein the co-polymer comprises:
a polymer polymerized with an amino sugar, or a polymer polymerized with an aminoglycoside, wherein an aptamer is covalently attached directly or via one or more linkers to a repeat unit of the co-polymer, and wherein the aptamer is a polypeptide having a sequence at least 90% identical to SEQ ID NO:1 or at least 90% identical to SEQ ID NO:2.