PROCESS FOR PREPARING WATER DISPERSIONS CONTAINING HIGH CONCENTRATION OF NANO/SUBMICRON, HYDROPHOBIC, FUNCTIONAL COMPOUNDS AND WATER DISPERSIONS OBTAINABLE THEREFROM

摘要

The present invention provides a process for preparing a water dispersion containing a high concentration of nano/submicron, hydrophobic, functional compounds. The process is carried out by using a complex stabilizer having an HLB value of about 10 to about 17, comprising lecithin and at least one non-phospholipid selected from polysorbate, sucrose ester, and polyglycerol fatty acid ester; selecting a specific weight ratio of the hydrophobic functional compounds and the stabilizer; and using homogenization technique, media milling technique, and/or centrifugal technique. The water dispersion containing a high concentration of nano/submicron, hydrophobic, functional compound produced by the process of the invention has stable dispersibility and improved bioavailability, and can be applied to the fields of foods and pharmaceuticals.

主权项

1. A process for preparing a water dispersion containing a high concentration of nano/submicron, hydrophobic, functional compounds, which comprises the following steps:
formulating a complex stabilizer and water into a water solution containing a complex stabilizer, wherein said complex stabilizer has an HLB value of about 10 to about 17 and comprises lecithin and at least one non-phospholipid selected from polysorbate, sucrose ester, and polyglycerol fatty acid ester, incorporating hydrophobic, functional compounds into the water solution containing a complex stabilizer to form a non-homogenously mixed liquid wherein the weight ratio of the hydrophobic, functional compounds to the complex stabilizer is from 2:1 to 10:1, subjecting the non-homogenously mixed liquid to a homogenization pretreatment to form a homogenously mixed liquid, subjecting the homogenously mixed liquid to nano-grade wet grinding to form the water dispersion, and optionally, subjecting the water dispersion from nano-grade wet grinding to a centrifugal step and collecting the supernatant, provided that the process does not include the step of formulating the water dispersion into an emulsion.