摘要 |
Disclosed herein is an implant comprising extant BMP-2 bound to demineralized bone, wherein the extant BMP-2 and demineralized bone are each derived from a single cadaver or live donor. Harvest cancellous bone and cortical bone from donor Grind harvested bone and substantially homogenous mixture of cortical and cancellous bone Expose harvested bone mixture to acetic acid lysing agent Rinse the harvested bone mixture with a rinsing agent Substantially neutralize the pH of the harvested bone mixture Dehydrate the harvested bone mixture |