IL-13 BINDING PROTEINS AND USES THEREOF

摘要

Novel anti-IL-13 antigen-binding proteins such as antibodies and antigen-binding fragments thereof are provided. Methods of using the proteins to reduce IL-13 activity and to treat IL-13-associated diseases and conditions are further provided.

主权项

1. An isolated antigen binding protein or a fragment thereof that binds human IL-13, comprising a variable heavy (VH) domain and a variable light (VL) domain, wherein the VH domain comprises HCDR1, HCDR2 and HCDR3 and the VL domain comprises LCDR1, LCDR2 and LCDR3, and wherein:
HCDR1 comprises the amino acid sequence of SEQ ID NO: 13; HCDR2 comprises the amino acid sequence of SEQ ID NO: 14; HCDR3 comprises the amino acid sequence of SEQ ID NO: 15; LCDR1 comprises the amino acid sequence having the formula:
GGNLX1LX2LX3LX4LX5LVH wherein LX1 is selected from the group consisting of L and M, LX2 is selected from the group consisting of L, I and V, LX3 is selected from the group consisting of G and A, LX4 is selected from the group consisting of S and A, and LX5 is selected from the group consisting of R and Y (SEQ ID NO:251); LCDR2 comprises the amino acid sequence having the formula:
DDLX6DRPS wherein LX6 is selected from the group consisting of G, I, E, M and Q (SEQ ID NO:252); and LCDR3 comprises the amino acid sequence having the formula:
QVWDTGSLX7PVV wherein LX7 is selected from the group consisting of D, R, L and S (SEQ ID NO:253).