Phenoxyethyl Cyclic Amine Derivatives and Their Activity as EP4 Receptor Modulators

摘要

The present invention provides a compound of the Formula (I): wherein X, R, R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein, or a pharmaceutically acceptable salt thereof.;

主权项

1. A compound of the formula: wherein X is: R is H, methyl, or ethyl; R1 is methyl, when R2 is H, and R1 is H when R2 is methyl; R3 is H or F; R4 is H, F, or methyl; R5 is OH, methyl, methoxy, or F; R6 is H when R7 is OH, and R6 is F when R7 is F; and R8 and R9 are each independently H or F; or a pharmaceutically acceptable salt thereof.