Labeled molecular imaging agents and methods of use

摘要

Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.

主权项

1. An imaging agent comprising a compound of Formula I wherein X is 18F, 3H, —(CH2)mZ, —CH2—O—(CH2)mZ, or —O—(CH2)mZ; Z is 18F or 3H; m is an integer between 1 and 5; Y is O—CH2, CH2—O, CH2—CH2, CH2—CH2—CH2, O—CH2—CH2, or CH2—O—CH2; and Ar is a 3-substituted phenyl, 4-substituted phenyl, 4-substituted naphthalene-1-yl, 5-substituted naphthalene-1-yl, or 6-substituted naphthalene-2-yl.