Peptide Compounds and Methods of Production and Use Thereof

摘要

Peptide compounds based on the CAP37 protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptides.

主权项

1. A composition comprising a peptide compound represented by Formula (I):
SM—XR-Pep-YR wherein: Pep is an amino acid sequence of one of SEQ ID NO:26 or SEQ ID NO:27; XR and YR are each independently 0, 1, 2, 3, 4, 5, or 6 arginine residues, with the proviso that (XR+YR) is 4, 5, or 6 arginine residues; and SM is a solubilizing moiety of one of (1)-(3), wherein:
(1) is 2-(2-amino-ethoxy)-ethoxy]acetic acidk (AEEAk), where k=1-5;(2) is {2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-acetic acidk (AEEEAk), where k=1-5; or(3) is a combination of AEEAm and AEEEAn subunits, wherein m=1-9 and n=1-9 with the proviso that (m+n) is 2, 3, 4, 5, 6, 7, 8, 9, or 10, and wherein the AEEAm and AEEEAn subunits may be arranged in any order.