发明名称 USE OF ISOXAZOLINE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF ARTHROPOD INFESTATIONS IN POULTRY
摘要 The present invention relates to methods of treating or preventing arthropod infestations of poultry animals and methods of controlling arthropod infestations in poultry animal's environment by administering an isoxazoline compound of formula (I) via drinking water.;
申请公布号 US2016317502(A1) 申请公布日期 2016.11.03
申请号 US201415105197 申请日期 2014.12.19
申请人 INTERVET INTERNATIONAL B.V. ;INTERVET INC. 发明人 Heckeroth Anja Regina;Zoller Hartmut;Flochlay-Sigognault Annie;Huyghe Bruno
分类号 A61K31/42 主分类号 A61K31/42
代理机构 代理人
主权项 1. A method of preventing or treating an infestations of a laying hen by a temporary parasitic arthropod comprising administering via the drinking water an effective amount of an isoxazoline compound of formula (I) Wherein R1=halogen, CF3, OCF3, CN, n=integer from 0 to 3, R2═C1-C3-haloalkyl, T=5- or 6-membered ring, which is optionally substituted by one or more radicals Y, Y=methyl, halomethyl, halogen, CN, NO2, NH2—C═S, or two adjacent radicals Y form together a chain; Q=X—NR3R4 or a 5-membered N-heteroaryl ring, which is optionally substituted by one or more radicals; X═CH2, CH(CH3), CH(CN), CO, CS, R3=hydrogen, methyl, haloethyl, halopropyl, halobutyl, methoxymethyl, methoxyethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, N-phenyl-N-methyl-amino, haloethylaminocarbonylmethyl, haloethylaminocarbonylethyl, tetrahydrofuryl, methylaminocarbonylmethyl, (N,N-dimethylamino)-carbonylmethyl, propylaminocarbonylmethyl, cyclopropylaminocarbonylmethyl, propenylaminocarbonylmethyl, haloethylaminocarbonylcyclopropyl, wherein ZA=hydrogen, halogen, cyano, halomethyl (CF3); R4=hydrogen, ethyl, methoxymethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, methylcarbonyl, ethylcarbonyl, propylcarbonyl, cyclopropylcarbonyl, methoxycarbonyl, methoxymethylcarbonyl, aminocarbonyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, haloethylaminocarbonylmethyl, cyanomethylaminocarbonylmethyl, or haloethylaminocarbonylethyl; or R3 and R4 together form a substituent selected from the group consisting of: or a salt or solvate thereof.
地址 Boxmeer NL