| 摘要 |
<p>Process for preparing carbapenem derivative of the formula [I], which comprises subjecting azetidinone compound of the formula [II] to intramolecular cyclization reaction together with elimination reaction of the group of -SR<4>, followed by re-adding said group of -SR<4> to the 2-position of the carbapenem skeleton of the intramolecularly cyclized compound, which is industrially useful as process for preparing carbapenem antimicrobials or synthetic intermediate therefor. <CHEM> wherein R<1> is protected or unprotected hydroxy-substituted lower alkyl group, R<2> is hydrogen atom or ester residue, R<3> is hydrogen atom or lower alkyl group, and the group of -SR<4> is group which can be used as substituent at 2-position of the carbapenem antimicrobials.</p> |
