| 摘要 |
<p>The present invention is related to a pharmaceutical composition comprising cyclosporin as an active component. More specifically, the present invention is related to a pharmaceutical composition comprising cyclosporin solid-state microemulsion prepared by dispersing of cyclosporin microemulsion in enteric carrier. Cyclosporin solid-state microemulsion prepared according to the said description is characterized in that it does not dissolve in such external phases as artificial gastric fluid. But it can dissolve in artificial intestinal fluid, thereby getting the microemulsion form having small particle size and releasing cyclosporin rapidly. The pharmaceutical composition according to the present invention can maintain the blood concentration of cyclosporin within therapeutic range for about 1 day through only one dosing per day. Therefore, it is possible to avoid the adverse effects induced by the additional increasing of the peak level of blood cyclosporin concentration in the conventional cyclosporin preparation, and furthermore, a convenience for administration can be obtained.</p> |
