A NOVEL PROCESS FOR THE SYNTHESIS OF BORON ENRICHED MAGNETIC NANOPARTICLES

摘要

The preparation method of the boron enriched magnetic nanoparticles includes steps of: (a) reacting hydroxyl substituted magnetic nanoparticles with 3-chloropropyltriethoxysilane and 3-aminopropyltriethoxysilane to form silyl amine and silyl chloride tagged magnetic nanoparticles; (b) reacting silyl amine tagged magnetic nanoparticles with o-carborane aldehyde to form carborane-appended magnetic nanoparticles; and (c) reacting silyl chloride tagged magnetic nanoparticles with 1-methyl-o-carborene in presence of n-butyllithium to form carborane-appended magnetic nanoparticles. The boron enriched magnetic nanoparticles are nontoxic and shows the magnetic property at room temperature. Hopefully, these boron enriched magnetic nanoparticles would deliver sufficient amount of boron within tumor cells with minimal toxicity and to perform biological evaluation.