发明名称 |
T cell-redirected antigen-binding molecule for cells having immunosuppression function |
摘要 |
The present invention provides an antigen-binding molecule that exhibits an excellent antitumor effect greater than exhibited by conventional antigen-binding molecules, as a result of the antigen-binding molecule: cross-linking T cells and cells having an immune response suppressing function; and inducing damage to the cells having the immune response suppressing function. The antigen-binding molecule includes: a domain (1) that binds to molecules expressed on the surface of cells having the immune response suppressing function; and a domain (2) that binds to a T cell receptor complex. |
申请公布号 |
AU2015260230(A1) |
申请公布日期 |
2016.11.17 |
申请号 |
AU20150260230 |
申请日期 |
2015.05.13 |
申请人 |
Chugai Seiyaku Kabushiki Kaisha;Osaka University |
发明人 |
Igawa, Tomoyuki;Ishiguro, Takahiro;Sakaguchi, Shimon;Nishikawa, Hiroyoshi |
分类号 |
C12N15/00;A61K39/395;A61P15/00;A61P35/00;A61P35/02;C07K16/28;C07K16/46 |
主分类号 |
C12N15/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|