发明名称 |
Process for the preparation of 7 alpha-alkoxycephem derivatives |
摘要 |
There is provided a process for preparing a compound of the formula (I): <IMAGE> (I) wherein R1 is an organic residue, R2 is a hydrogen or a chlorine atom, a methoxy, ethoxy or an acetoxy group, and n represents 0, 1 or 2. The process comprises reacting a compound of the formula (II): <IMAGE> (II) wherein R2 and n are as defined above, with an inorganic or organic nitrite, in an alcohol R1OH, wherein R1 is as defined above, or in a mixture R1OH-organic solvent in the presence of an inorganic or organic acid. The compounds of the formula (I) are known intermediates in the synthesis of human leucocyte elastase inhibitors (HLE).
|
申请公布号 |
US5254680(A) |
申请公布日期 |
1993.10.19 |
申请号 |
US19910691089 |
申请日期 |
1991.04.25 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
ALPEGIANI, MARCO;BISSOLINO, PIERLUIGI;D'ANELLO, MATTEO;PERRONE, ETTORE |
分类号 |
A61K31/545;A61K31/546;A61P31/04;A61P43/00;C07D501/00;C07D501/04;(IPC1-7):C07D501/04 |
主分类号 |
A61K31/545 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|