摘要 |
Herpesvirus protease inhibitor 4H-3,1-benzoxazin-4-one, 4H-thieno[3,2-d][1,3]oxazin-4-one, and 4H-thieno[2,3-d][1,3]oxazin-4-one derivatives which are 2-substituted by -C(XY)-R1, -C(XY)-CH2-R1, -C(XY)-C2H4-R1, or -CX=CY-R1 wherein one of X and Y is hydrogen, halo or C1-6 alkyl and the other is hydrogen or C1-6 alkyl, and R1 is aryl or heteroaryl, substituted by ZR4 wherein Z is CO, NRxCO, NRxCOCO, NRxCOCH2, or NRxSO2 wherein Rx is hydrogen or C1-6 alkyl, and R4 is aryl or heteroaryl, substituted by NRzOH wherein Rz is hydrogen or C1-6 alkyl; and pharmaceutically acceptable salts thereof.
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申请人 |
SMITHKLINE BEECHAM PLC;FENWICK, ASHLEY, EDWARD;GRIBBLE, ANDREW, DERRICK;HAIGH, DAVID;SLINGSBY, BRIAN, PETER |
发明人 |
FENWICK, ASHLEY, EDWARD;GRIBBLE, ANDREW, DERRICK;HAIGH, DAVID;SLINGSBY, BRIAN, PETER |