| 摘要 |
PCT No. PCT/US94/05861 Sec. 371 Date Apr. 23, 1996 Sec. 102(e) Date Apr. 23, 1996 PCT Filed May 25, 1994 PCT Pub. No. WO94/27649 PCT Pub. Date Dec. 8, 1994A system of the present invention for applying a substance to an applied area includes a patch (11), as well as apparatus (12, 14, 16, 18 and 21) and methods for making the same. The patch includes backing material (52) and a tri-laminate (54), with a dose of medication sealed therebetween in reservoir (62). To facilitate and increase transdermal and/or topical application of the medication to the applied area, such as the skin of a user, the tri-laminate includes a layer material (68) having at least one opening therein (64), which permits the medication to flow through each opening without tearing or ripping the layer of material covering the reservoir.
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