发明名称 |
Inhibitors of farnesyl-protein transferase |
摘要 |
The present invention is directed to substituted benozdiazepine compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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申请公布号 |
US5852010(A) |
申请公布日期 |
1998.12.22 |
申请号 |
US19970823920 |
申请日期 |
1997.03.25 |
申请人 |
MERCK & CO., INC. |
发明人 |
GRAHAM, SAMUEL L.;ANTHONY, NEVILLE J.;WAI, JOHN S. |
分类号 |
C07D243/24;C07D403/12;(IPC1-7):C07D243/24;A61K31/395 |
主分类号 |
C07D243/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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