| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound which has a high optical purity and is useful as a raw material for medicines and agrochemicals. SOLUTION: A compound of formula I [R1 is an alkyl, (substituted) phenyl or a (substituted) aralkyl; R2 is anα-amino acid residue; R3 is hydrogen, methyl or methoxy; * means to be optically active], for example, 0, 0'-di p-toluoyl-D- tartaric acid.mono-L-(1,2-dibenzyloxycarbonyl) ethylamide. The compound of formula I can be produced, for example, by reacting an optically active amino acid ester of formula III (for example, L-asparaginic acid dibenzyl ester.para- toluene sulfonic acid salt) with an optically active diacyltartaric acid anhydride of formula IV (for example, 0, 0'-di para-toluoyl-D-tartaric acid anhydride) in a solvent at 0 to 100 deg.C, more preferably at room temperature to 40 deg.C, for 0.1 to 5.0 hr, if necessary, after a neutralization reaction giving a free state. |
