发明名称 |
Melanocortin receptor-3 ligands to treat sexual dysfunction |
摘要 |
Methods for treating sexual dysfunction, such as erectile dysfunction or sexual arousal disorder, with a compound having the generic formula X1-X2-(D)Phe-Arg-(D)Trp-X3. A particularly useful compound is HP-228, which has the formula Ac-Nle-Gln-His-(D)Phe-Arg-(D)Trp-Gly-NH2. The invention also provides methods for selecting melanocortin receptor-3 ligands by determining whether a compound modulates the activity of MC-3 as an agonist or antagonist. These methods can be used to screen compound libraries for ligands to treat MC-3-associated conditions. Such conditions include sexual dysfunction, including erectile dysfunction and sexual arousal disorder. |
申请公布号 |
AU6605800(A) |
申请公布日期 |
2001.02.05 |
申请号 |
AU20000066058 |
申请日期 |
2000.07.13 |
申请人 |
TREGA BIOSCIENCES, INC. |
发明人 |
KEVIN C. DINES;TIMOTHY C. GAHMAN;BEVERLY E GIRTEN;DOUGLAS L. HITCHIN;KEVIN R HOLME;HENGYUAN LANG;SANDRA R. SLIVKA;KAREN J. WATSON-STRAUGHAN;RONALD R. TUTTLE;YAZHONG PEI |
分类号 |
A61K31/4184;A61K31/454;A61K38/06;A61K38/07;A61K38/08;A61K38/33;G01N33/566 |
主分类号 |
A61K31/4184 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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