发明名称 |
Process for preparing temozolomide |
摘要 |
<p>Described is a new process for producing temozolomide, comprising the reaction between 5-aminoimidazole-4-carboxamide and N-succinimidyl-N'-methyl carbamate and the subsequent reaction of the thus obtained carbamoyl 5-aminoimidazole-4-carboxamide with sodium nitrite. Temozolomide is then purified by chromatography on adsorbent polymeric resin and subsequent crystallization from water and acetone.</p> |
申请公布号 |
EP2151442(A2) |
申请公布日期 |
2010.02.10 |
申请号 |
EP20090166077 |
申请日期 |
2009.07.22 |
申请人 |
CHEMI SPA |
发明人 |
TURCHETTA, STEFANO;DE FERRA, LORENZO;ZENONI, MAURIZIO;ANIBALDI, MAURO |
分类号 |
C07D487/04 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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