| 摘要 |
Nucleocapsid-like particles (NLPs) formed from recombinant orthomyxoviral nucleoprotein (NP) and single-stranded RNA (ssRNA) and having a rod-like structure are provided which are capable of eliciting an improved antibody response against NP when compared to monomeric NP. The NP comprised by the NLPs may be derived from influenza virus and optionally be fused to a peptide that comprises one or more epitopes from another influenza protein, such as the M2e peptide. The NLPs have use as vaccines for protection against influenza virus infections. |
