发明名称 |
MUTANT INTERLEUKIN-2 POLYPEPTIDES |
摘要 |
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the ±-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof. |
申请公布号 |
HRP20160917(T1) |
申请公布日期 |
2016.09.23 |
申请号 |
HR2016P000917T |
申请日期 |
2016.07.21 |
申请人 |
Roche Glycart AG |
发明人 |
Ast, Oliver;Bruenker, Peter;Freimoser-Grundschober, Anne;Herter, Sylvia;Hofer, Thomas U.;Hosse, Ralf;Klein, Christian;Moessner, Ekkehard;Nicolini, Valeria G.;Umana, Pablo |
分类号 |
C07K14/55;A61K39/395;A61K47/48;C12N15/26 |
主分类号 |
C07K14/55 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|