| 发明名称 | Human anti-human influenza virus antibody | ||
| 摘要 | Provided is a human antibody having a neutralization activity against a human influenza virus. More specifically, provided is a human antibody which recognizes a highly conserved region in a human influenza A virus subtype H3N2 or a human influenza B virus and has a neutralization activity against the virus. The human antibody is a human anti-human influenza virus antibody, which has a neutralization activity against a human influenza A virus subtype H3N2 and binds to a hemagglutinin HA1 region of the human influenza A virus subtype H3N2, or which has a neutralization activity against a human influenza B virus, and includes, as a base sequence of a DNA encoding a variable region of the antibody, a sequence set forth in any one of SEQ ID NOS: 5 to 12. | ||
| 申请公布号 | US9493550(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201414505515 | 申请日期 | 2014.10.03 |
| 申请人 | Osaka University;The Research Foundation for Microbial Diseases of Osaka University | 发明人 | Ikuta Kazuyoshi;Koketsu Ritsuko;Okuno Yoshinobu;Yunoki Mikihiro;Ideno Shoji;Oshita Masatoshi;Kuhara Motoki;Momota Masatoshi |
| 分类号 | C07K16/10;A61K39/00 | 主分类号 | C07K16/10 |
| 代理机构 | Kilyk & Bowersox, P.L.L.C. | 代理人 | Kilyk & Bowersox, P.L.L.C. |
| 主权项 | 1. An isolated human anti-human influenza virus monoclonal antibody, comprising a variable region comprising: a heavy chain comprising the amino acid sequence of SEQ ID NO: 31 and a light chain comprising the amino acid sequence of SEQ ID NO: 32; or a heavy chain comprising the amino acid sequence of SEQ ID NO: 33 and a light chain comprising the amino acid sequence of SEQ ID NO: 34. | ||
| 地址 | Osaka JP | ||