Simulated moving bed chromatographic separation process

摘要

The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, wherein the apparatus has a plurality of zones comprising at least a first zone and a second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA product being separated from different components of the feed mixture in each zone.

主权项

1. A composition, comprising a PUFA product, wherein the PUFA product is EPA present in an amount greater than 93 wt %, wherein the composition comprises an amount of ω-6 polyunsaturated fatty acids up to 0.40 wt %, and wherein the composition comprises an amount of eicosatetraenoic acid up to 1 wt %.