Azepane derivatives and methods of treating hepatitis B infections

摘要

Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

主权项

1. A compound of Formula V: or a pharmaceutically acceptable salt thereof; wherein each R1 is, independently at each occurrence, halo, OH, —C1-C6 alkyl, or —O—C1-C6 alkyl, wherein the alkyl group is optionally substituted 1-3 times with halo or OH; each R2 is, independently at each occurrence, halo, OH, —C1-C6 alkyl, or —O—C1-C6 alkyl, wherein the alkyl group is optionally substituted 1-3 times with halo or OH; Cy is R11 is, independently at each occurrence, —OH, —C1-C6 alkyl, —OC(O)CH3, or —C3-C10 cycloalkyl; R13 and R14, together with the carbons to which they are attached, join to form a cyclopropyl ring; m is 1, 2, or 3; n is 1, 2, or 3; and x is 2 or 3.