| 发明名称 | Humanized pertussis antibodies and uses thereof | ||
| 摘要 | The present invention relates to humanized antibodies which bind the pertussis toxin protein and their use as therapeutic agents. In particular, the present invention is directed to improved humanized 1B7 and 11E6 antibodies which bind the pertussis toxin protein. | ||
| 申请公布号 | US9512204(B2) | 申请公布日期 | 2016.12.06 |
| 申请号 | US201514675514 | 申请日期 | 2015.03.31 |
| 申请人 | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;SYNTHETIC BIOLOGICS, INC. | 发明人 | Maynard Jennifer;Nguyen Annalee;Padlan Eduardo;Wagner Ellen |
| 分类号 | A61K39/40;C07K16/12;A61K45/06;A61K39/00 | 主分类号 | A61K39/40 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. |
| 主权项 | 1. A humanized 1B7 antibody that binds a pertussis toxin protein, comprising an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein the immunoglobulin heavy chain variable region comprises the amino acid sequence of SEQ ID NO1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, or SEQ ID NO:6; and the immunoglobulin light chain variable region comprises the amino acid sequence of SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, or SEQ ID NO:12. | ||
| 地址 | Austin TX US | ||