POLYSACCHARIDE VACCINE FOR STAPHYLOCOCCAL INFECTIONS

摘要

PROBLEM TO BE SOLVED: To provide polysaccharide vaccine for Staphylococcal infections.SOLUTION: The invention relates to compositions of a deacetylated poly N-acetylated glucosamine (dPNAG) of Staphylococci. The dPNAG may be isolated from natural sources or synthesized de novo. The invention also relates to the use of dPNAG as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative or coagulase-positive Staphylococci, and other organisms carrying the ica (intracellular adhesion) locus. The invention further provides methods of use for antibodies directed to dPNAG, particularly for inducing passive immunity to the same level of infections.SELECTED DRAWING: None