| 摘要 |
Described is a mutant of a protein or variant thereof which causes a disease after having performed a conformational transition. This disease comprises neurodegenerative diseases such as Transmissible Spongiform Encelphalopathy (TSE), Alzheimers disease, Multiple Sclerosis, and Parkinsons disease; and/or other conformational diseases such as Primary systematic amyloidosis, Type II diabetes, and Atrial amyloidosis. The mutant protein or a variant thereof comprises at least one additional engineered disulphide bond which inhibits a conformational transition od such proteins in humans and animals. Also described is a nucleic acid sequence coding for the mutant of the protein or variant and the use of the mutant protein, variant, or the nucleic acid in the preparation of a medicament for the treatment of conformational diseases.
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