| 发明名称 |
Immunotoxins directed against malignant cells |
| 摘要 |
The present invention relates to immunotoxins, that effectively kill malignant cells having a given surface marker and nucleic acid constructs encoding them. These reagents comprise a toxic moiety that is derived from a Rana pipiens protein having ribonucleolytic activity linked to an antibody capable of specific binding with a chosen tumor cell.
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| 申请公布号 |
US6395276(B1) |
申请公布日期 |
2002.05.28 |
| 申请号 |
US19980071672 |
申请日期 |
1998.05.01 |
| 申请人 |
IMMUNOMEDICS, INC.;IMMUNOMEDICS INC |
发明人 |
RYBAK SUSANNA M.;NEWTON DIANNE L.;GOLDENBERG DAVID M. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/43;A61K39/395;A61K47/48;A61P35/00;A61P35/02;A61P43/00;C07K14/46;C07K16/28;C07K16/30;C07K16/46;C07K19/00;C12N9/22;C12Q1/34;(IPC1-7):A61K39/395;A61K39/385;A61K39/00;C12P21/08 |
主分类号 |
C12N15/09 |
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