发明名称 |
Liposomal analgesic drug compositions prepared in GMV using an ammonium sulfate gradient |
摘要 |
Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising 'GMV' (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
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申请公布号 |
US7357944(B2) |
申请公布日期 |
2008.04.15 |
申请号 |
US20040771305 |
申请日期 |
2004.02.05 |
申请人 |
NEW YORK UNIVERSITY;YISSUM RESEARCH DEVELOPMENT, CO |
发明人 |
BOLOTIN ELIJAH M.;GRANT GILBERT J.;BARENHOLZ YECHEZKEL;TURNDORF HERMAN;PISKOUN BORIS |
分类号 |
A61K9/127;A61H1/02;A61K31/445;A61K47/02;A61K47/44;A61P23/02;A63B21/00;A63B21/005;A63B21/22;A63B22/04;A63B23/035;A63B23/04 |
主分类号 |
A61K9/127 |
代理机构 |
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