发明名称 |
Methods of inhibiting binding of beta-sheet fibril to rage and consequences thereof |
摘要 |
This invention provides a method of inhibiting the binding of beta-sheet fibril to RAGE on the surface of a cell which comprises contacting the cell with a binding-inhibiting amount of a compound capable of inhibiting binding of beta-sheet fibril to RAGE so as to thereby inhibit binding of beta-sheet fibril to RAGE. In one embodiment, the beta-sheet fibril is amyloid fibril. In one embodiment, the compound is sRAGE or a fragment thereof. In another embodiment, the compound is an anti-RAGE antibody or portion thereof. This invention provides the above method wherein the inhibition of binding of the beta-sheet fibril to RAGE has the consequences of decreasing the load of beta-sheet fibril in the tissue, inhibiting fibril-induced programmed cell death, and inhibiting fibril-induced cell stress. This invention also provides methods of determining whether a compound inhibits binding of a beta-sheet fibril to RAGE on the surface of a cell.
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申请公布号 |
US2009028882(A1) |
申请公布日期 |
2009.01.29 |
申请号 |
US20080009572 |
申请日期 |
2008.01.18 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
STERN DAVID M.;YAN SHI DU;SCHMIDT ANN MARIE |
分类号 |
A61K38/16;G01N33/53;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P1/02;A61P3/06;A61P3/10;A61P9/10;A61P9/12;A61P13/12;A61P15/10;A61P17/00;A61P21/00;A61P25/00;A61P27/02;A61P29/00;A61P31/00;A61P35/00;A61P37/02;C07K14/47;C07K14/705;C07K16/28;C12N5/06;C12Q1/02;C12R1/91;G01N33/68 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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