发明名称 |
PREVENTIVE OR REMEDY FOR INFLAMMATORY DISEASE |
摘要 |
<p>The present inventors obtained, from a phage library of human antibodies, an anti-mouse NR 10 neutralizing antibody-expressing BM095 clone that shows a strong proliferation-suppressing activity in an IL-31-dependent Ba/F3 cell proliferation assay system. When this anti-mouse NR 10 neutralizing antibody was administered to NC/Nga mice, a model of atopic dermatitis which is a mouse model of chronic dermatitis that arises as a result of repeated applications of picryl chloride, a mouse model of rheumatoid arthritis, and a mouse model of osteoarthritis, a significant effect of symptom suppression was observed. This revealed that the anti-NR 10 neutralizing antibody is indeed effective as a therapeutic agent for inflammatory diseases. In addition, the present inventors successfully obtained an anti-human NR 10 neutralizing antibody, providing extremely useful therapeutic agents with practical clinical applications.</p> |
申请公布号 |
EP2047863(A4) |
申请公布日期 |
2009.12.09 |
申请号 |
EP20070744945 |
申请日期 |
2007.06.08 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
HASEGAWA, MASAKAZU;KITAMURA, HIDETOMO;ADACHI, HIDEKI;KASUTANI, KEIKO |
分类号 |
A61K45/00;A61K39/395;A61P1/04;A61P1/16;A61P11/06;A61P17/02;A61P19/02;A61P21/04;A61P29/00;A61P37/00;A61P37/08;C07K16/28;C12N15/02 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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