| 发明名称 | Antibody specifically binding synovial microvasculature of arthritis patients | ||
| 摘要 | The present invention provides an antigen binding polypeptide which specifically targets the synovial microvasculature of arthritis patients and comprises one or more complementarity determining regions (CDRs) selected from the group consisting of SEQ ID NOs 1 to 4. The present invention also relates to the use of such antigen binding polypeptides and conjugates thereof for use in the diagnosis and treatment of arthritis. | ||
| 申请公布号 | US9416174(B2) | 申请公布日期 | 2016.08.16 |
| 申请号 | US201113877097 | 申请日期 | 2011.09.30 |
| 申请人 | QUEEN MARY AND WESTFIELD COLLEGE UNIVERSITY OF LONDON | 发明人 | Pitzalis Constantino |
| 分类号 | C07K16/00;C07K16/46;A61K39/395;A61K39/44;C07K16/18;C07K16/28 | 主分类号 | C07K16/00 |
| 代理机构 | Marshall, Gerstein & Borun LLP | 代理人 | Marshall, Gerstein & Borun LLP |
| 主权项 | 1. An antibody or antigen binding fragment thereof which specifically targets the synovial microvasculature of arthritis patients and comprises: (i) the VH sequence as shown in SEQ ID NO: 9; and (ii) the VL sequence as shown in SEQ ID NO: 10. | ||
| 地址 | London GB | ||