| 主权项 |
1. A compound, or a stereoisomer of said compound, or a pharmaceutically acceptable salt of said compound or said stereoisomer, said compound having the structural Formula (I): or a tautomer thereof having the structural Formula (I′): or pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of H, lower alkyl, lower heteroalkyl, lower cycloalkyl, and -(lower alkyl)-(lower cycloalkyl) wherein each said lower alkyl, lower heteroalkyl, lower cycloalkyl, and -(lower alkyl)-(lower cycloalkyl) is optionally substituted with fluoro; ring A is selected from the group consisting of aryl, monocyclic heteroaryl, monocyclic cycloalkyl, monocyclic cycloalkenyl, monocyclic heterocycloalkyl, monocyclic heterocycloalkenyl, and a multicyclic group; each R2A (when present) is independently selected from the group consisting of: halo, oxo, —OH, —CN, —SF5, —OSF5, —NO2, —Si(R5)3, —N(R6)2, —OR6, —SR6, alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl, wherein said alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl of R2A are each optionally unsubstituted or substituted with one or more groups independently selected from R8; m is 0 or more; ring B is selected from the group consisting of a 6-membered aryl, 6-membered cycloalkyl, 6-membered cycloalkenyl, 6-membered heteroaryl, a 6-membered heterocycloalkyl, and a 6-membered heterocycloalkenyl ring, wherein each said heteroatom containing ring comprises from 1 to 4 ring heteroatoms independently selected from the group consisting of N, N-oxide, O, S, S(O), and S(O)2; each R2B (when present) is independently selected from the group consisting of halo, —CN, alkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, heteroalkyl, haloalkyl —O-alkyl, —O-cycloalkyl, —O-alkyl-cycloalkyl, —O-heteroalkyl, and —O-haloalkyl; n is 0 or more; ring C is selected from the group consisting of aryl, monocyclic heteroaryl, monocyclic cycloalkyl, monocyclic cycloalkenyl, monocyclic heterocycloalkyl, monocyclic heterocycloalkenyl, and a multicyclic group; each R2 (when present) is independently selected from the group consisting of: halo, oxo, —OH, —CN, —SF5, —OSF5, —Si(R5)3, —N(R6)2, —NR7C(O)R6, —NR7S(O)2R12, —NR7S(O)2N(R6)2, —NR7C(O)N(R6)2, —NR7C(O)OR6, —C(O)R6, —C(O)2R6, —C(O)N(R6)2, —S(O)R12, —S(O)2R12, —S(O)2N(R6)2, —OR6, —SR6, alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, -alkyl-heteroaryl, heterocycloalkyl, and -alkyl-heterocycloalkyl, wherein said alkyl, haloalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, -alkyl-heteroaryl, heterocycloalkyl, and -alkyl-heterocycloalkyl of R2C are each optionally unsubstituted or substituted with one or more groups independently selected from R8; p is 0 or more; R4 is selected from the group consisting of lower alkyl and lower haloalkyl; each R5 (when present) is independently selected from the group consisting of alkyl, heteroalkyl, haloalkyl, cycloalkyl, and -alkyl-cycloalkyl; each R6 (when present) is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl, wherein each said alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl of R6 is unsubstituted or substituted with one or more groups independently selected from halo, —CN, —OH, lower alkyl, lower cycloalkyl, lower heteroalkyl, lower haloalkyl, lower —O-alkyl, lower —O-heteroalkyl, and lower —O-haloalkyl; each R7 (when present) is independently selected from the group consisting of H, alkyl, heteroalkyl, haloalkyl, cycloalkyl, -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl, wherein each said cycloalkyl, -alkyl-cycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl of R7 is unsubstituted or substituted with one or more groups independently selected from halo, —CN, lower alkyl, lower cycloalkyl, lower heteroalkyl, lower haloalkyl, lower —O-alkyl, lower —O-heteroalkyl, and lower —O-haloalkyl; each R8 (when present) is independently selected from the group consisting of halo, oxo, —OH, —CN, —SF5, —OSF5, alkyl, —O-alkyl, haloalkyl, haloalkoxy, —C(O)OR11, cycloalkyl, -alkyl-cycloalkyl, —O-cycloalkyl, —O-alkyl-cycloalkyl, —O-benzyl, heteroalkyl, —O-heteroalkyl, and -alkyl-OH; R9 is selected from the group consisting of H, halo, alkyl, cycloalkyl, haloalkyl, and heteroalkyl; R10 is selected from the group consisting of H, halo, alkyl, cycloalkyl, haloalkyl, and heteroalkyl; R11 (when present) is selected from the group consisting of H, lower alkyl, lower heteroalkyl, lower cycloalkyl, and -alkyl-(lower cycloalkyl); and each R12 (when present) is independently selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl, wherein each said alkyl, alkenyl, alkynyl, heteroalkyl, haloalkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, -alkyl-aryl, heteroaryl, and -alkyl-heteroaryl of R12 is unsubstituted or substituted with one or more groups independently selected from halo, —CN, —OH, lower alkyl, lower cycloalkyl, lower heteroalkyl, lower haloalkyl, lower —O-alkyl, lower —O-heteroalkyl, and lower —O-haloalkyl. |
