TRANSDERMAL PATCH FORMULATIONS FOR DELIVERY OF WATER SOLUBLE DRUGS, PEPTIDES, PROTEINS AND OLIGOSACCHARIDES

摘要

The present invention relates to patch formulations for the transdermal delivery of water soluble drugs, peptides, proteins and oligosaccharides. The patch formulations are intended for the delivery of water soluble drugs, peptides, proteins and oligosaccharides across a plurality of pre-formed aqueous microchannels in the skin. The patch formulations contain a water soluble drug, peptides, proteins or oligosaccharide dispersed in a non-adhesive biodegradable polymer and are manufactured via film casting of polymer solutions containing dispersed drug, peptide, protein or oligosaccharide onto a suitable backing material. Both rapid release formulations and prolonged release formulations are disclosed.