| 发明名称 |
METHODS AND COMPOSITIONS FOR INDUCING REGULATORY T-CELL GENERATION |
| 摘要 |
The present invention provides, among other things, methods and compositions for modulating inflammation. The present invention is based, in part, on the surprising discovery that peripheral regulatory T cells (pTreg), can be induced to differentiate after exposure to bacterial metabolites. In some embodiments, provided methods and compositions are used to treat diseases resulting from inflammation. |
| 申请公布号 |
US2016271086(A1) |
申请公布日期 |
2016.09.22 |
| 申请号 |
US201415033145 |
申请日期 |
2014.10.31 |
| 申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
Rudensky Alexander;Arpaia Nicholas |
| 分类号 |
A61K31/19;G01N33/50 |
主分类号 |
A61K31/19 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inducing differentiation of regulatory T cells (Treg), the method comprising steps of:
administering to cells undergoing inflammation a composition comprising a histone deacetylase (HDAC) inhibitory agent. |
| 地址 |
New York NY US |
