| 摘要 |
PROBLEM TO BE SOLVED: To accurately identify a naphthoyl indole-based drug, which is a comprehensive regulation object, even when a standard sample is unavailable or no registration is made in databases.SOLUTION: The following measurements are executed repeatedly (S2-S3): an MRM measurement in which used as the measurement condition is plural MRM transitions according to different masses of a functional group R3, with a naphthoyl as a precursor ion, and a naphthalene as a product ion with respect to the target sample; an MRM measurement in which used as the measurement condition is plural MRM transitions according to different masses of a functional group R2, with an indole carbonyl as a precursor ion, and an indole from which the carbonyl group separated as a product ion; and a precursor ion scan measurement with an indole carbonyl, in the state of the functional group R2 being added and a functional group R1 being eliminated, as a product ion. The presence or absence of a basic skeleton is determined from the conformity of the peak positions on chromatograms obtained by three kinds of MS/MS measurements (S5-S7), and the kind of each functional group is estimated from an MRM transition, etc. in which ions have been detected, to identify a naphthoyl indole-based drug (S9-S10). |
