Immune methods against influenza viruses and combinatorial vaccines thereof

摘要

The invention provides a method of preventing the spreading of influenza viruses, and the factors making up the said method, and especially provides one type of combinatorial vaccine and the immunization method thereof. Two of more influenza vaccines are inoculated by a certain sequence, and each influenza vaccine vaccines is inoculated at least once, and the inoculation take place two or more times; wherein each influenza vaccine includes one or more antigens, the immunogenic fragments thereof, or the coding genes thereof, and further includes a different antigen, the immunogenic fragments or the coding gene of the different antigen.

主权项

1. A universal influenza immunization method against multiple influenza strains, comprising inoculating a subject with two or more different influenza vaccines in a certain sequence, wherein the subject is inoculated with each influenza vaccine at least once, and the inoculations take place two or more times; wherein each influenza vaccine includes one or more antigens, the immunogenic fragments thereof, or the coding genes thereof, and further includes a different antigen, the immunogenic fragments of the different antigen, or the coding gene of the different antigen,
(i) wherein three immunizations are carried out in sequence, and
(a) the first immunization is an H1 vaccine in which the hemagglutinin (HA) is from an H1 subtype of influenza A;(b) the second immunization is an H3 vaccine in which the HA is from an H3 subtype of influenza A;(c) the third immunization is an H5 vaccine in which the HA is from an H5 subtype of influenza A; (ii) wherein three immunizations are carried out in sequence, and all the immunizations are H1 vaccines in which the HA is from an H1 serotype influenza A; or (iii) wherein four immunizations are carried out in sequence, and
(a) the first immunization is a BHA vaccine in which the HA is from influenza B;(b) the second immunization is an H1 vaccine in which the HA is from an H1 subtype of influenza A;(c) the third immunization is an H3 vaccine in which the HA is from an H3 subtype of influenza A; and(d) the fourth immunization is an H5 vaccine in which the HA is from an H5 subtype of influenza A.