Pharmaceutical compositions for the treatment of cancer and other diseases or disorders

摘要

This invention provides novel pharmaceutical compositions of the compound of formula (I):;
or a pharmaceutically acceptable salt thereof, that are suitable for the bulk production of an oral pharmaceutical dosage form; processes for the production of said oral pharmaceutical dosage form; and the use of the pharmaceutical composition for the treatment of patients suffering from or subject to diseases, disorders, or conditions involving cell survival, proliferation and migration, including chronic inflammatory proliferative disorders, proliferative ocular disorders, benign proliferative disorders, and cancer.

主权项

1. A method for treating Aurora A kinase mediated cancer, comprising the administration of a therapeutically effective amount of a liquid pharmaceutical composition comprising a sodium salt of formula (II): or a crystalline form thereof, wherein the pharmaceutical composition comprises about 0.10% w/w to about 2% w/w of the compound of formula (II), or a crystalline form thereof; about 0.20% to about 3% w/w of buffer, wherein the buffer is sodium bicarbonate; and a solvent mixture of propylene glycol, purified water, PEG400, and optionally glycerin; wherein the solvent contains less than about 50% purified water, and the composition contains at least about 15% w/w propylene glycol and at least about 15% w/w PEG400.